導師簡介
張博宇，男，2013年于中國科學院大連化學物理研究所獲博士學位，師從李燦院士。2013年在中國科學院大連化學物理研究所工作。2016年到澳門大學健康科學學院從事博士後研究，2018年加入全国最大的信誉平台，從事分子與納米診療相關研究工作。
研究方向
研究方向主要為分子與納米診療。目前研究興趣包括：1）氣體遞質熒光探針；2）生物正交催化及其應用；3）非酒精脂肪肝光診療。
招生專業、方向
臨床檢驗診斷學；醫學技術-醫學檢驗技術；醫學技術-衛生檢驗與檢疫
在讀研究生情況
3名在讀研究生
聯系方式
郵箱:byzhang@dmu.edu.cn; coreyzhang@hotmail.com電話: 15840956372
撰寫專著
《熒光染料及其生物醫學應用》；彭孝軍，樊江莉等著（參與其中兩章編寫）；出版社：化學工業出版社；ISBN：9787122400383；出版時間：2022-03-01
科研文章
1. Y. Wu, B. Zhang, H. Xu, M. He, X. Deng, L. Zhang, Q. Dang, J. Fan, Y. Guan, X. Peng and W. Sun,Coordination Chemistry Reviews, 2023,480.Title:"The Chronological Evolution of Fluorescent Gpcr Probes for Bioimaging."DOI:10.1016/j.ccr.2023.215040.
2. P. Xiao, D. Guo, L. Yan, H. Xu, Y. Ma, J. Liu, J. Yang, W. Sun and B. Zhang,Analyst, 2022,147, 1798-1802.Title:"A Pegylated Water-Soluble Fluorescent and Colorimetric Probe for Carbon Monoxide Detection."DOI:10.1039/d2an00118g.
3. Z. Wu, Q. Yang, Y. Liu, B. Zhang, R. Li, W. Wang, J. Wang, K. Domen, F. Wang and F. Fan,ACS Catalysis, 2022,12, 3063-3082.Title:"Can Li: A Career in Catalysis."DOI:10.1021/acscatal.1c06034.
4. Y. Wu, X. Deng, L. Ye, W. Zhang, H. Xu and B. Zhang,Molecules, 2022,27.Title:"A Tcf-Based Carbon Monoxide Nir-Probe without the Interference of Bsa and Its Application in Living Cells."DOI:10.3390/molecules27134155.
5. X. Deng, Y. Wu, H. Xu, J. Yan, H. Liu and B. Zhang,Chem Commun (Camb), 2022,58, 12518-12527.Title:"Recent Research Progress in Galactose-Based Fluorescent Probes for Detection of Biomarkers of Liver Diseases."DOI:10.1039/d2cc04180d.
6. B. Zhang, F. Wang, H. Zhou, D. Gao, Z. Yuan, C. Wu and X. Zhang,Angew Chem Int Ed Engl, 2019,58, 2744-2748.Title:"Polymer Dots Compartmentalized in Liposomes as a Photocatalyst for in Situ Hydrogen Therapy."DOI:10.1002/anie.201813066.
7. D. Gao, B. Zhang, Y. Liu, D. Hu, Z. Sheng, X. Zhang and Z. Yuan,Theranostics, 2019,9, 5315-5331.Title:"Molecular Engineering of near-Infrared Light-Responsive Bodipy-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics."DOI:10.7150/thno.34418.
8. G. Feng, B. Zhang, S. Wang, Z. Ding, G. Li and X. Zhang,Sensors and Actuators B: Chemical, 2019,301, 127090.Title:"Ratiometric Atp Detection on Gliding Microtubules Based on Bioorthogonal Fluorescence Conjugation."DOI:10.1016/j.snb.2019.127090.
9. P. Chen, K. Wang, B. Zhang, W. Guo, Y. Liu and C. Li,Chem Commun (Camb), 2019,55, 12813-12816.Title:"Water Enables an Asymmetric Cross Reaction of Alpha-Keto Acids with Alpha-Keto Esters for the Synthesis of Quaternary Isotetronic Acids."DOI:10.1039/c9cc06356k.
10. F. Zhou, B. Zhang, H. Liu, Z. Wen, K. Wang and G. Chen,Organic Process Research & Development, 2018,22, 504-511.Title:"Facile Preparation of N-Alkyl-2-Pyrrolidones in a Continuous-Flow Microreactor."DOI:10.1021/acs.oprd.7b00392.
11. F. Zhou, H. Liu, Z. Wen, B. Zhang and G. Chen,Industrial & Engineering Chemistry Research, 2018,57, 11288-11298.Title:"Toward the Efficient Synthesis of Pseudoionone from Citral in a Continuous-Flow Microreactor."DOI:10.1021/acs.iecr.8b02367.
12. B. Zhang, S. Wang, J. Tan and X. Zhang,Dyes and Pigments, 2018,155, 186-193.Title:"Unique Fluorescence of Boronic Acid Derived Salicylidenehydrazone Complexes with Two Perpendicular Ict: Solvent Effect on Pet Process."DOI:10.1016/j.dyepig.2018.03.046.
13. B. Zhang, G. Feng, S. Wang and X. Zhang,Dyes and Pigments, 2018,149, 356-362.Title:"Boronic Acid Derived Salicylidenehydrazone Complexes for Wash-Free Fluorescence Imaging of Cellular Organelles."DOI:10.1016/j.dyepig.2017.10.027.
14. S. Wang, B. Zhang, W. Wang, G. Feng, D. Yuan and X. Zhang,Chemistry, 2018,24, 8157-8166.Title:"Elucidating the Structure-Reactivity Correlations of Phenothiazine-Based Fluorescent Probes toward Clo()."DOI:10.1002/chem.201800356.
15. G. Feng, B. Zhang, C. Wang, J. Tan, S. Wang, Z. Ding and X. Zhang,Sensors and Actuators B: Chemical, 2018,277, 320-327.Title:"Construction of Ratiometric Fluorescent Probe Based on Inverse Electron-Demand Diels–Alder Reaction for Ph Measurement in Living Cells."DOI:10.1016/j.snb.2018.09.022.
16. F. Zhou, B. Zhang, C. Yao, K. Zhu, M. Yang and G. Chen,Chemical Engineering & Technology, 2016,39, 849-856.Title:"Cyclization of Pseudoionone Catalyzed by Sulfuric Acid in a Microreactor."DOI:10.1002/ceat.201500670.
17. J. Wei, W. Guo, B. Zhang, Y. Liu, X. Du and C. Li,Chinese Journal of Catalysis, 2014,35, 1008-1011.Title:"An Amphiphilic Organic Catalyst for the Direct Asymmetric Michael Addition of Cycloketone to Nitroolefins in Water."DOI:10.1016/s1872-2067(14)60080-2.
18. W. Guo, X. Wang, B. Zhang, S. Shen, X. Zhou, P. Wang, Y. Liu and C. Li,Chemistry, 2014,20, 8545-8550.Title:"Facile Synthesis of Chiral Spirooxindole-Based Isotetronic Acids and 5-1h-Pyrrol-2-Ones through Cascade Reactions with Bifunctional Organocatalysts."DOI:10.1002/chem.201402945.
19. B. Zhang, Z. Jiang, X. Zhou, S. Lu, J. Li, Y. Liu and C. Li,Angew Chem Int Ed Engl, 2012,51, 13159-13162.Title:"The Synthesis of Chiral Isotetronic Acids with Amphiphilic Imidazole/Pyrrolidine Catalysts Assembled in Oil-in-Water Emulsion Droplets."DOI:10.1002/anie.201206438.
20. B. Zhang, Z. Jiang, J. Li, Y. Zhang, F. Lin, Y. Liu and C. Li,Journal of Catalysis, 2012,287, 5-12.Title:"Catalytic Oxidation of Thiophene and Its Derivatives Via Dual Activation for Ultra-Deep Desulfurization of Fuels."DOI:10.1016/j.jcat.2011.11.003.
21. F. Lin, Y. Zhang, L. Wang, Y. Zhang, D. Wang, M. Yang, J. Yang, B. Zhang, Z. Jiang and C. Li,Applied Catalysis B: Environmental, 2012,127, 363-370.Title:"Highly Efficient Photocatalytic Oxidation of Sulfur-Containing Organic Compounds and Dyes on Tio2 with Dual Cocatalysts Pt and Ruo2."DOI:10.1016/j.apcatb.2012.08.024.
教改文章
1.劉煥英，蔡靜，于旭蓉，楊春光，張博宇*.《工程化學》課程思政的創新教學案例分析[J].廣州化工, 2019, 47(13):206-208+213。2019年7月08日。rccse武大核心及以上核心期刊
2.劉煥英*，于旭蓉，蔡靜，楊春光，張博宇，專業基礎課程《工程化學》思政改革的探索[J].廣州化工, 2019, 47(18):144-146+176。rccse武大核心及以上核心期刊，2019年9月23日
獲獎
教學：檢驗醫學院2022年教師教學大賽二等獎
大連醫科大學教師教學大賽獲獎名單優秀獎
大連醫科大學第三屆PBL教學案例撰寫比賽獲獎者三等獎李柄谕、李發勝、劉娜、燕小梅、張博字、秦倩
大創：2022年大連醫科大學大學生創新創業訓練計劃項目一等獎
大連醫科大學第八屆“互聯網+”大學生創新創業大賽三等獎
教育立項
1.大連醫科大學教學改革研究項目，虛拟仿真技術輔助醫用化學實驗教學的嘗試與探索，白天語，劉娜，馬慧朋，羅紅，張博宇，孫文平，袁金婵, DYLX22051，0.2萬元
科研立項
大連科技之星: 2019RQ060 10萬元;
遼甯省面上項目: 2019-MS-091, 5萬元;
橫向經費: 505327, 505533, 505598合計到賬9萬元.
